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12-tetraoxatetradecanamido)-2-(((R)-1
Chemical Name: (4-amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2
InChi: InChI=1S/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8
88(1-2):1-9
Tec and Btk rather than Lyn kinase auto-phosphorylation in COS cells
LY2606368 dihydrochloride or® 526 SE 12-tetraoxatetradecanamido)-2-(((R)-1Prexasertib, also known as LY2606368, is a potent and selective Chk1 Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B T cell progenitor acute lymphoblastic leukemia. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1 Dependent Mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX positive double stranded DNA breaks in the S phase cell population.
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